Development of 177Lu-phytate Complex for Radiosynovectomy
نویسندگان
چکیده مقاله:
Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>99.9 %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology
منابع مشابه
development of 177lu-phytate complex for radiosynovectomy
objective(s): in this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. materials and methods: lu-177 of 2.6-3 gbq/mg specific activity was obtained by irradiation of natural lu2o3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. the product was converted into chloride form which was further used for labeling of 177lu-phytate complex and che...
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introduction: rheumatoid arthritis (ra) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. radiosynovectomy (rsv) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. se...
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عنوان ژورنال
دوره 16 شماره 5
صفحات 705- 709
تاریخ انتشار 2013-05-01
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